By Witold Lasek,Radoslaw Zagozdzon,Marek Jakóbisiak
This e-book discusses the immunotherapeutic power of Interleukin 12 within the context of scientific oncology, in addition to antitumor results proven in preclinical reviews and scientific trials in melanoma immunotherapy. because of its skill to turn on either innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been considered as a promising candidate for tumor immunotherapy. notwithstanding, regardless of the encouraging leads to animal types, simply very modest antitumor results were proven in early scientific trials. lately, a number of medical reviews were initiated within which IL-12 was once utilized as an adjuvant in melanoma vaccines, in gene remedy together with locoregional injections of IL-12 plasmid, and within the kind of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
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